Guidelines for handling CAR T cell side effects
Their work, published in Nature Reviews Clinical Oncology , confronts the two main side effects of chimeric antigen receptor T-cells, known as CAR T cells , white blood cells genetically engineered to strike cells with a specific target on their surface. "CAR T cells provide an entirely new level of improved disease response among patients with certain blood cancers and hold promise for more wide-ranging use," said Elizabeth Shpall, M.D., deputy chair and professor of Stem Cell Transplantation and Cellular Therapy at MD Anderson. "The algorithms that we published are conservative, detailed, and will help us save lives as we move forward with these exciting but also more toxic therapies," Shpall said. The review covers wide-ranging research on CAR T therapies by many institutions and includes insights based on more than 100 patients treated at MD Anderson, Moffitt Cancer Center in Tampa, Sylvester Cancer Center at the University of Miami, and Mayo Clinic Ca...